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KMID : 1037020230120020071
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Medical Lasers; Engineering, Basic Research, and Clinical Application
2023 Volume.12 No. 2 p.71 ~ p.83
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Boron delivery systems for enhanced boron neutron capture therapy: a comprehensive review
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Yu Seung-Jin
Choi Go-Eun
Choy Jin-Ho
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Abstract
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Boron neutron capture therapy (BNCT) is a promising cancer-treatment strategy that involves the induction of nuclear fission reactions via the interaction of low-energy thermal neutrons with boron (10B), enabling selective tumor-cell apoptosis. For BNCT to be effective, achieving a high degree of localization of 10B atoms within the tumor cells is crucial. Currently, the clinical use of the two U.S. Food and Drug Administration (FDA)-approved drugs for BNCT, sodium mercaptoundecahydro-closo-dodecaborate (BSH) and boronophenylalanine (BPA), is restricted by their low uptake and low tumor-to-blood selectivity. Ongoing efforts are focused on developing high-uptake boron delivery agents with pharmacokinetic characteristics that enable high-efficiency BNCT. This review provides a comprehensive overview of the recent developments in boron delivery strategies for BNCT.
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KEYWORD
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Boron neutron capture therapy, Radiotherapy, Cancer, Drug delivery system, Boron-containing agent
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